PYP Imaging in Conjunction with Cardiac Amyloid Clinic

PYP Imaging in Conjunction with Cardiac Amyloid Clinic

Guest: Omar F. Abou Ezzeddine, M.D., C.M., M.S. (@abouezzeddine)

Host: Paul A. Friedman, M.D. (@drpaulfriedman)

There has been a revolution in the diagnosis of amyloid heart disease: Nuclear imaging has made endomyocardial biopsy the exception, rather than the rule.

Joining us today to discuss the role of nuclear imaging in the diagnosis of amyloid heart disease is Omar F. Abou Ezzeddine, M.D., C.M., M.S., a consultant in Cardiovascular Medicine and director of the Cardiac Sarcoid Clinic at Mayo Clinic in Rochester, Minnesota.

Specific topics discussed:

• Types of amyloid that infiltrate the heart muscle and cause myocardial toxicity
• Pyrophosphate (PYP) detection of those amyloids
• PYP imaging limitations and drawbacks, including risk of false-positives and false-negatives
• Limitations of single-photon emission computerized tomography (SPECT) imaging
• Pros and cons of hybrid SPECT-CT vs. SPECT-alone imaging
• Role of PYP imaging in assessment of therapeutic response

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV.

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Podcast episode transcript found here.