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The Cardiovascular CME podcast is a free educational offering from Mayo Clinic, featuring content geared towards physicians, physician assistants, and nurse practitioners who are interested in exploring a multitude of cardiology-related topics. Tune in and subscribe to explore today’s most pressing cardiology topics with your colleagues at Mayo Clinic and gain valuable insights that can be directly applied to your practice. No CME credit offered for podcast episodes at this time.
Episodes

Tuesday Apr 05, 2022
New Standard Therapy for Heart Failure with Reduced Ejection Fraction
Tuesday Apr 05, 2022
Tuesday Apr 05, 2022
New Standard Therapy for Heart Failure with Reduced Ejection Fraction - When and How to Introduce SGLT2 Inhibitors
Guest: Margaret M. Redfield, M.D.
Host: Malcolm R. Bell, M.D.
A new class of agents with powerful effects on cardiovascular outcomes has quickly amassed a compelling body of evidence for its use: sodium-glucose cotransporter-2 (SGLT2) inhibitors.
Joining us today to discuss the use of SGLT2 inhibitors for the treatment of patients with heart failure with reduced ejection fraction (HFrEF) is Margaret M. Redfield, M.D., a cardiologist and heart failure specialist at Mayo Clinic in Rochester, Minnesota.
Specific topics discussed:
- Evidence supporting the use of SGLT2 inhibitors in patients with HFrEF
- Treatment impact on patients with heart and renal failure
- Patients who are ineligible for use of SGLT2 inhibitors
- How to select patients and begin treatment in the outpatient setting, including titration requirements
- Collaboration with specialists managing care for patients with diabetes
- Inpatient treatment
- Overcoming hesitation among cardiologists in prescribing SGLT2 inhibitors
- Considerations for the treatment of patients who present with diabetic ketoacidosis
Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV.
NEW Cardiovascular Education App:
The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!
No CME credit offered for this episode.
Podcast episode transcript found here.

Thursday Mar 31, 2022
STEMI/NSTEMI and OMI/NOMI Paradigms
Thursday Mar 31, 2022
Thursday Mar 31, 2022
STEMI/NSTEMI and OMI/NOMI Paradigms
Guest: Stephen W. Smith, M.D.
Host: Anthony H. Kashou, M.D.
Early detection of acute myocardial infarction (MI) can impact patients' immediate care and long-term outcomes. Most trained physicians can detect common ST-elevation MI (STEMI) patterns on ECG. However, a subset of patients does not present with common STEMI patterns. There are ECG patterns that can be identified to improve patient outcomes but are not yet widely known or accepted in current guidelines.
Joining us today to discuss the STEMI versus non-STEMI (NSTEMI) and occlusion MI (OMI) versus nonocclusion MI (NOMI) paradigms is Stephen W. Smith, M.D., Emergency Medicine, Hennepin Healthcare, in Minneapolis.
Specific topics discussed:
- The problem with the STEMI versus NSTEMI dichotomy
- Subgroup within the NSTEMI cohort that may benefit from emergent reperfusion therapy
- ECG findings to watch for — beyond, standard STEMI findings — that indicate an occluded artery
- Access to Dr. Smith's evaluation formula
- Patterns to watch for in diagnosis of OMI
- Benign mimickers
- Key takeaways for the novice interpreter
- Other clinical factors to watch for that may indicate OMI
- Recommendations for emergency medicine providers
Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.
Facebook: MayoCVservices
LinkedIn: Mayo Clinic Cardiovascular Services
NEW Cardiovascular Education App:
The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!
No CME credit offered for this episode.
Podcast episode transcript found here.

Tuesday Mar 29, 2022
Imaging in HCM
Tuesday Mar 29, 2022
Tuesday Mar 29, 2022
Imaging in HCM
Guest: Jeffrey B. Geske, M.D. (@jeffreygeske)
Host: Kyle W. Klarich, M.D. (@KyleWKlarich)
ACA/AHA guidelines related to hypertrophic cardiomyopathy were modified in 2020. Although recommendations for the diagnosis of adult patients reflect minimal change, guidelines for the diagnosis of pediatric patients include new cutoffs. From an imaging perspective, the decision-making algorithm for sudden cardiac death risk stratification incorporates variables not present in prior guidelines.
Joining us today to discuss imaging in hypertrophic cardiomyopathy is Jeffrey B. Geske, M.D., Cardiology, at Mayo Clinic in Rochester, Minnesota.
Specific topics discussed:
- Benefits of echocardiography and cardiac MRI in hypertrophic cardiomyopathy
- Scar burden and guidelines for quantification
- Imaging guidelines for apical variant hypertrophic cardiomyopathy
- Recommendations for frequency of cardiac MRI related to delayed gadolinium enhancement
- Role of serial imaging in the clinical management of patients
- Best methods to assess dynamic outflow tract obstruction in hypertrophic cardiomyopathy
- Use of squat-to-stand and valsalva maneuvers
- Changes pertaining to imaging for hypertrophic cardiomyopathy in the 2020 ACA/AHA guidelines
Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV.
NEW Cardiovascular Education App:
The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!
No CME credit offered for this episode.
Podcast episode transcript found here.

Tuesday Mar 22, 2022
New HCM Guidelines
Tuesday Mar 22, 2022
Tuesday Mar 22, 2022
New HCM Guidelines
Guest: Steve R. Ommen, M.D. (@SteveOmmen)
Host: Kyle W. Klarich, M.D. (@KyleWKlarich)
The distinguished chair of the writing committee for the AHA/ACC 2020 hypertrophic cardiomyopathy guidelines discusses key points in the evolution of guidelines since 2011.
Joining us today to discuss current hypertrophic cardiomyopathy guidelines is Steve R. Ommen, M.D., a cardiologist and the director of the Hypertrophic Cardiomyopathy Clinic at Mayo Clinic in Rochester, Minnesota.
Specific topics discussed:
- Major changes to the guidelines
- Importance of allowing patients to participate in informed decisions related to their care
- Advocating for the role of comprehensive hypertrophic cardiomyopathy centers
- Clarification of screening of children and adolescents
- Risk stratification for sudden cardiac death
- Emerging implications for use of septal reduction therapies
- Healthy lifestyles and exercise risks and benefits
- Guidelines accessibility on American College of Cardiology and American Heart Association apps
- Concept of shared decision making and incorporation of the risk calculator into conversation with the patient
- Revisions to risk factors for sudden cardiac death
- Discrepancies with 2014-2015 European Society of Cardiology guidelines
- Partnership and teamwork between comprehensive hypertrophic cardiomyopathy centers and non-center-based cardiologists
- Guidelines for screening of adolescents
- Recommendations for active healthy lifestyles and competitive athletes
- Cautions regarding patients with hypertrophic cardiomyopathy who develop atrial fibrillation
Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV.
NEW Cardiovascular Education App:
The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!
No CME credit offered for this episode.
Podcast episode transcript found here.

Thursday Mar 17, 2022
Evolution of Computerized ECG Interpretation
Thursday Mar 17, 2022
Thursday Mar 17, 2022
Evolution of Computerized ECG Interpretation
Guest: Peter Macfarlane, Ph.D., D.Sc.
Host: Anthony H. Kashou, M.D.
In the 1960s, investigative works for the methods to analyze electrocardiograms (ECGs) with automated techniques were conducted at the University of Glasgow. The evolution of the University of Glasgow's ECG interpretation software — now used worldwide — has shaped the ECG criteria used in clinical practice today.
Joining us today to discuss ECG analysis is Peter Macfarlane, Ph.D., D.Sc., the lead developer of the program. He is a University of Glasgow emeritus professor and honorary senior research fellow who in 2014 was awarded a Commander of the British Empire for his services to health care.
Specific topics discussed:
- History of ECG analysis at the University of Glasgow
- Other researchers involved in early ECG interpretation and development
- Key features required and criteria needed to recognize sinus rhythm
- What the process of commercial development looked like
- Clinical trials and studies that validated the work
- Impact of age, sex, race and ethnicity on the ECG
- The future of the Glasgow technique in electrocardiography
Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.
Facebook: MayoCVservices
LinkedIn: Mayo Clinic Cardiovascular Services
NEW Cardiovascular Education App:
The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!
No CME credit offered for this episode.
Podcast episode transcript found here.

Tuesday Mar 15, 2022
PYP Imaging in Conjunction with Cardiac Amyloid Clinic
Tuesday Mar 15, 2022
Tuesday Mar 15, 2022
PYP Imaging in Conjunction with Cardiac Amyloid Clinic
Guest: Omar F. Abou Ezzeddine, M.D., C.M., M.S. (@abouezzeddine)
Host: Paul A. Friedman, M.D. (@drpaulfriedman)
There has been a revolution in the diagnosis of amyloid heart disease: Nuclear imaging has made endomyocardial biopsy the exception, rather than the rule.
Joining us today to discuss the role of nuclear imaging in the diagnosis of amyloid heart disease is Omar F. Abou Ezzeddine, M.D., C.M., M.S., a consultant in Cardiovascular Medicine and director of the Cardiac Sarcoid Clinic at Mayo Clinic in Rochester, Minnesota.
Specific topics discussed:
- Types of amyloid that infiltrate the heart muscle and cause myocardial toxicity
- Pyrophosphate (PYP) detection of those amyloids
- PYP imaging limitations and drawbacks, including risk of false-positives and false-negatives
- Limitations of single-photon emission computerized tomography (SPECT) imaging
- Pros and cons of hybrid SPECT-CT vs. SPECT-alone imaging
- Role of PYP imaging in assessment of therapeutic response
Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV.
NEW Cardiovascular Education App:
The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!
No CME credit offered for this episode.
Podcast episode transcript found here.

Tuesday Mar 08, 2022
PET Imaging for Cardiac Sarcoidosis in Conjunction with Cardiac Sarcoid Clinic
Tuesday Mar 08, 2022
Tuesday Mar 08, 2022
PET Imaging for Cardiac Sarcoidosis in Conjunction with Cardiac Sarcoid Clinic
Guest: Omar F. Abou Ezzeddine, M.D., C.M., M.S. (@abouezzeddine)
Host: Paul A. Friedman, M.D. (@drpaulfriedman)
Positron emission tomography (PET) imaging can help diagnose and manage heart disease in a way that eliminates the need for heart tissue samples and replaces more complex, less effective imaging approaches.
Joining us today to discuss PET imaging for cardiac sarcoidosis is Omar F. Abou Ezzeddine, M.D., C.M., M.S., a consultant in Cardiovascular Medicine and director of the Cardiac Sarcoidosis Clinic at Mayo Clinic in Rochester, Minnesota.
Specific topics discussed:
- Introduction to sarcoidosis
- Rationale behind the use of PET imaging to assess for cardiac sarcoidosis
- When to suspect cardiac sarcoidosis
- Necessity of whole-body imaging for diagnosis
- Comparison of magnetic resonance imaging and PET imaging and a role for hybrid imaging
- Artificial intelligence applications for PET imaging
Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV.
NEW Cardiovascular Education App:
The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!
No CME credit offered for this episode.
Podcast episode transcript found here.

Thursday Mar 03, 2022
Computerized ECG Interpretation Software
Thursday Mar 03, 2022
Thursday Mar 03, 2022
Computerized ECG Interpretation Software
Guest: Ian Rowlandson
Hosts: Anthony H. Kashou, M.D. and Peter A. Noseworthy, M.D. (@noseworthypeter)
Since the first human electrocardiogram (ECG) was recorded in 1887, the clinical use, means to interpret and ability to record cardiac biosignals have continued to evolve. Computerized electrocardiography software has helped with ECG interpretation, improved clinical workflow, and advanced the understanding of electrophysiology.
Joining us today to discuss computerized electrocardiography is Ian Rowlandson, a biomedical engineer and chief scientist of diagnostic cardiology at GE Healthcare, which supplies Mayo Clinic's ECG technology.
Specific topics discussed:
- Development of computerized electrocardiography software
- Evolution of the automated ECG interpretation process
- Interpretation and benefits of serial ECG comparison
- Common challenges in the development of ECG algorithms
- Common diagnoses that are difficult for ECG algorithms to capture
- Changes, including artificial intelligence, expanding the focus of ECG interpretation
- Future of computerized electrocardiography
Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.
Facebook: MayoCVservices
LinkedIn: Mayo Clinic Cardiovascular Services
NEW Cardiovascular Education App:
The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!
No CME credit offered for this episode.
Podcast episode transcript found here.

Tuesday Mar 01, 2022
HFpEF Diagnosis and Treatment in the Cath Lab
Tuesday Mar 01, 2022
Tuesday Mar 01, 2022
HFpEF Diagnosis and Treatment in the Cath Lab
Guest: Barry A. Borlaug, M.D.
Host: Malcolm R. Bell, M.D.
Heart failure with preserved ejection fraction (HFpEF), formerly referred to as diastolic heart failure, is defined hemodynamically as an inability of the heart to pump blood adequately at normal filling pressures. But while some people have high filling pressures while at rest, others have high filling pressures during exercise. Diagnosis of HFpEF in the Cardiac Catheterization Laboratory involves both at-rest and exercise studies.
Joining us today to discuss the diagnosis of HFpEF and patient selection for Cardiac Catheterization Laboratory testing is Barry A. Borlaug, M.D., a cardiologist at Mayo Clinic in Rochester, Minnesota.
Specific topics discussed:
- HFpEF defined
- Diagnosis and patient selection for catheterization laboratory testing
- H2FpEF scoring system
- Catheterization laboratory at-rest and exercise studies, tests and measurements
- Key parameters for HFpEF diagnosis
- General study length
- Treatment recommendations
- Cardiac rehabilitation considerations
Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV.
NEW Cardiovascular Education App:
The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!
No CME credit offered for this episode.
Podcast episode transcript found here.

Tuesday Feb 22, 2022
Inclisiran – How Does it Really Work?
Tuesday Feb 22, 2022
Tuesday Feb 22, 2022
Inclisiran – How Does it Really Work?
Guest: R. Scott Wright, M.D.
Host: Stephen Kopecky, M.D. (@DrSteveKopecky)
In 2021, the U.S. Food and Drug Administration (FDA) approved the use of inclisiran to lower low-density lipoprotein (LDL) cholesterol in people with atherosclerotic cardiovascular disease.
Joining us today to discuss inclisiran is R. Scott Wright, M.D., a cardiologist at Mayo Clinic in Rochester, Minnesota. Dr. Wright was intimately involved in planning recent studies of inclisiran and reporting the results.
Specific topics discussed:
- How inclisiran works
- FDA-identified indications for use
- Administration and dosing
- Cost of the drug
- LDL cholesterol reduction results
- Initial and long-term side effects
- Long-term benefits and studies
- Inclisiran and lipoprotein (a)
- Off-target effects and drug-drug interaction monitoring
- The ideal patient and patients who are not appropriate to receive inclisiran
- Research outcomes for patients who are statin intolerant
Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV.
NEW Cardiovascular Education App:
The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!
No CME credit offered for this episode.
Podcast episode transcript found here.